| Abstract | This research delves into the neurobiological mechanisms by which Plasmodium falciparum (Pf) manipulates Anopheles mosquito behavior to enhance malaria transmission. Recent evidence suggests that Pf secretes bioactive metabolites that alter mosquito neural signaling, increasing attraction to infected hosts. By focusing on how these metabolites affect mosquito chemosensory and neural pathways, our study aims to identify key communication points between the parasite and vector. Understanding this neurobiological manipulation opens the path to developing innovative vector control strategies that disrupt the parasite’s ability to influence mosquito behavior, offering new, sustainable solutions for malaria prevention. |
| Where does this project lie in the translational pathway? | T1 - Basic Research,T3 - Evidence into Practice |
| Expected Outputs | The PhD project is expected to produce significant scientific outputs, including high-impact publications. These findings will be presented at key international conferences, furthering the understanding of parasite-vector interactions. Translational outcomes include the development of innovative, eco-friendly vector control tools, such as metabolite-based bait traps, aimed at disrupting malaria transmission pathways. The project is also anticipated to secure additional funding from bodies like the MRC and global health organisations, while contributing to malaria eradication efforts by reducing transmission rates in endemic regions. Moreover, the PhD student will acquire extensive skills in quantitative and interdisciplinary research, enhancing their leadership in future infectious disease control initiatives. These outcomes will strengthen research collaborations and have a lasting impact on malaria control strategies. |
| Training Opportunities | The student will have access to a wide range of training opportunities throughout the PhD project. They will gain technical skills in advanced analytical techniques, including NMR and GC-MS for analysis, as well as chemical fractionation methods. Hands-on experience with omics approaches like RNA sequencing, proteomics, and metabolomics will further enhance their expertise. Additionally, training in 3D tracking systems for behavioral analysis will allow for the quantification of mosquito behaviors, while instruction in statistical modeling and machine learning will support the analysis of complex datasets. Collaborative work with experts from neurobiology, parasitology, analytical chemistry, and vector biology will foster interdisciplinary research skills. The student will also receive guidance in experimental design and research methodology, along with opportunities to present their findings at conferences, enhancing their communication skills. Professional development workshops will cover grant writing and scientific ethics, and there may be opportunities for fieldwork or collaboration with vector control programs, providing practical experience in real-world applications of their research. This comprehensive training will equip the student with a robust skill set essential for a successful career in malaria research and related fields. |
| Skills Required | The ideal student should possess a strong background in relevant chemistry and biological sciences, particularly in parasitology, entomology, analytical chemistry or molecular biology. Experience with laboratory techniques, such as molecular cloning, DNA/RNA extraction, and basic analytical methods, is essential. Familiarity with statistical analysis and data management software will be beneficial for handling complex datasets. The student should also have experience or coursework in bioinformatics and an understanding of omics technologies. Strong problem-solving skills, attention to detail, and the ability to work independently as well as collaboratively in a team setting are crucial. Additionally, effective communication skills, both written and verbal, will be important for presenting research findings and collaborating with interdisciplinary teams. A genuine interest in vector-borne diseases and a passion for innovative research in malaria transmission will also be key attributes. |
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Key Publications associated with this project |
Emami S.N. et al., (2017), A key malaria metabolite modulates vector blood seeking, feeding, and susceptibility to infection. Science, 335: 1076-1080: PMID:28183997 |
| Emami, S. N. et al., (2017), The transmission potential of malaria- infected mosquitoes (An.gambiae-Keele, An.arabiensis-Ifakara) is altered by the vertebrate blood type they consume during parasite development. Scientific reports,7, 40520: PMID:28094293. | |
| Stromsky V.E. et al., (2021), Plasmodium metabolite HMBPP stimulates feeding of main mosquito vectors on blood and artificial toxic sources, Communications Biology- Nature group. DOI: 10.1111/boc.202000039. |