LSTM Professors Lalloo and Jaffar, in partnership colleagues at St Georges University of London, published findings from a large phase 3 trial of novel therapies for the management of cryptococcal meningitis, a serious opportunistic infection that occurs in the advanced stages of HIV. The research led to an immediate change in WHO guidelines, which in turn is leading to changes in policy and practice. Both professors are partners in a new phase 3 trial of Ambisome therapy for cryptococcal meningitis, being led by LSHTM and St Georges University of London.