Antimicrobial resistance mechanisms and transfer

Antimicrobial resistance mechanisms and transfer

Project 19 May 2021
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Understanding the fundamental mechanisms of resistance, and how this resistance is able to spread between bacterial replicons within a bacterial cell (transposition) and between bacterial cells (e.g. conjugation), allows us to design strategies which may halt or minimise this spread. 

We have multiple projects determining mechanisms of resistance to various antimicrobials as well as characterising the mobile genetic elements, such as plasmids and transposons, which are responsible for the dissemination of this resistance amongst bacterial communities.

Our current activity here is funded by the MRC, NIHR and the ERDF.

Published studies

Moyo S, et al. Molecular characterisation of the first New Delhi metallo-β-lactamase 1-producing Acinetobacter baumannii from Tanzania. Transactions of the Royal Society for Tropical medicine and hygiene. 2021. https://doi.org/10.1093/trstmh/traa173

Yang Y, et al. Molecular characterization of carbapenem-resistant and virulent plasmids in Klebsiella pneumoniae from patients with bloodstream infections in China. Microbes and Infection. 2021. https://doi.org/10.1080/22221751.2021.1906163

Brouwer MSM, et al. Mobile colistin resistance gene mcr-1 detected on an IncI1 plasmid in Escherichia coli from meat. Journal of Global Antimicrobial Resistance. 2020. https://doi.org/10.1016/j.jgar.2020.08.018

Tansirichaiya S, et al. Capture of a novel, antibiotic resistance encoding, mobile genetic element from Escherichia coli using a new entrapment vector. Journal of Applied Microbiology. 2020. https://doi.org/10.1111/jam.14837

Nikolaou E, et al. Antibiotic Resistance Is Associated with Integrative and Conjugative Elements and Genomic Islands in Naturally Circulating Streptococcus pneumoniae Isolates from Adults in Liverpool, UK. Genes. 2020. https://doi.org/10.3390/genes11060625