International Glossina Genome Initiative (2014) Genome Sequence of the Tsetse Fly (Glossina morsitans): Vector of African Trypanosomiasis. Science 344 doi:10.1126/science.1249656.
Rose C, Belmonte R, Armstrong SD, Molyneux G, Haines LR, Lehane MJ, Wastling J, Acosta-Serrano A. (2014) An Investigation into the protein composition of the teneral Glossina morsitans morsitans peritrophic matrix. PLOS Neglected Tropical Diseases. 24;8(4):e2691. doi: 10.1371/journal.pntd.0002691.
Christoffels A, Masiga D, Berriman M, Lehane M, Touré Y, et al. (2014) International Glossina Genome Initiative 2004–2014: A Driver for Post-Genomic Era Research on the African Continent. PLoS Negl Trop Dis 8(8): e3024. doi:10.1371/journal.pntd.0003024
Alexandra P.M. Shaw, Inaki Tirados, Clement T.N. Mangwiro, Johan Esterhuizen, Michael J. Lehane, Stephen J. Torr, and Vanja Kovacic (2015) Costs of using ‘tiny targets’ to control Glossina fuscipes fuscipes, a vector of Gambiense sleeping sickness in Arua District of Uganda. PLoS Negl Trop Dis 9. e0003624
Tirados I, Esterhuizen J, Kovacic V, Mangwiro TNC, Vale GA, et al. (2015) Tsetse Control and Gambian Sleeping Sickness; Implications for Control Strategy. PLoS Negl Trop Dis 9. e0003822
Fabrice Courtin, Mamadou Camara, Jean-Baptiste Rayaisse, Moise Kagbadouno, Emilie Dama, Oumou Camara, Ibrahima S Traoré, Jérémi Rouamba, Moana Peylhard, Martin B Somda, Mamadou Leno, Mike J Lehane Steve J Torr, Philippe Solano, Vincent Jamonneau, Bruno Bucheton (2015) Reducing human-tsetse contact significantly enhances the efficacy of sleeping sickness active screening campaigns: a promising result in the context of elimination. PLoS NTD 9. e0003727
Glyn A. Vale, John W. Hargrove, Philippe Solano, Fabrice Courtin, Jean-Baptiste Rayaisse, Michael J. Lehane, Johan Esterhuizen, Inaki Tirados, and Stephen J. Torr (2015) Optimal Strategies for Controlling Riverine Tsetse Flies Using Targets: a Modelling Study PLoS NTD 9. e0003615
Ooi C-P, Haines LR, Southern DM, Lehane MJ, Acosta-Serrano A (2015) Tsetse GmmSRPN10 Has Anti-complement Activity and Is Important for Successful Establishment of Trypanosome Infections in the Fly Midgut. PLoS Negl Trop Dis 9. e3448
David P. Alt, Jennifer H. Wilson-Welder, Darrell O. Bayles, Caroline Cameron, Ben Adler, Dieter M. Bulach, Torsten Seemann Michael J. Lehane, Lee R. Haines, Alistair C. Darby, Neil Hall, Alan D. Radford, Richard L. Zuernera (2015) Complete Genome Sequence of Leptospira interrogans Serovar Bratislava, Strain PigK151 Genome Announcements 3(3):e00678-15. doi:10.1128/genomeA.00678-15.
Kovacic V, Tirados I, Esterhuizen J, Mangwiro CTN, Lehane MJ, et al. (2016) We Remember ... Elders' Memories and Perceptions of Sleeping Sickness Control Interventions in West Nile, Uganda. PLoS Negl Trop Dis 10. e0004745
Mantilla BS, Marchese L, Casas-Sanchez A, Dyer NA, Ejeh N, et al. (2017) Proline Metabolism is Essential for Trypanosoma brucei brucei Survival in the Tsetse Vector. PLoS Pathog 13(1): e1006158. https://doi.org/10.1371/journal.ppat.1006158
Rayaisse, J-B.; Mahamat, H. M.; Peka, M.; et al. (2017) Adding tsetse control to medical activities contributes to decreasing transmission of sleeping sickness in the Mandoul focus (Chad). TROPICAL MEDICINE & INTERNATIONAL HEALTH Volume: 22 Special Issue: SI Supplement: 1 Pages: 51-51 Meeting Abstract: 4S1.5
Tirados, Inaki; Mpembele, Fabrice; Bessell, Paul; et al. (2018) LARGE-SCALE USE OF INSECTICIDE-IMPREGNATED 'TINY TARGETS' TO CONTROL TSETSE FLIES IN THE DEMOCRATIC REPUBLIC OF CONGO. Conference: 67th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTHM) Location: New Orleans, LA Date: OCT 28-NOV 01, 2018 AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE Volume: 99 Issue: 4 Supplement: S Pages: 652-652 Meeting Abstract: 2073
Attardo et al. (2019) Comparative genomic analysis of six Glossina genomes, vectors of African trypanosomes. Genome Biology 20:187 https://doi.org/10.1186/s13059-019-1768-2
Trypa-NO! contributes to the elimination of gambiense human African trypanosomiasis by combining tsetse control with “screen, diagnose and treat” using innovative tools and strategies Ndung’u, Joseph Mathu, Boulangé, Alain, Picado, Albert, Mugenyi, Albert, Mortensen, Allan, Hope, Andrew, Mollo, Brahim Guihini, Bucheton, Bruno, Wamboga, Charles, Waiswa, Charles, Kaba, Dramane, Matovu, Enock, Courtin, Fabrice, Garrod, Gala, Gimonneau, Geoffrey, Bingham, Georgina V., Hassane, Hassane Mahamat, Tirados, Inaki, Saldanha, Isabel, Kabore, Jacques, Rayaisse, Jean-Baptiste, Bart, Jean-Mathieu, Lingley, Jessica, Esterhuizen, Johan, Longbottom, Joshua, Pulford, Justin, Kouakou, Lingue, Sanogo, Lassina, Cunningham, Lucas, Camara, Mamadou, Koffi, Mathurin, Stanton, Michelle, Lehane, Mike, Kagbadouno, Moise Saa, Camara, Oumou, Bessell, Paul, Mallaye, Peka, Solano, Philippe, Selby, Richard, Dunkley, Sophie, Torr, Steve, Biéler, Sylvain, Lejon, Veerle, Jamonneau, Vincent, Yoni, Wilfried and Katz, Zachary (2020) 'Trypa-NO! contributes to the elimination of gambiense human African trypanosomiasis by combining tsetse control with “screen, diagnose and treat” using innovative tools and strategies'. PLoS Neglected Tropical Diseases, Vol 14, Issue 11, e0008738.
Tirados, Inaki, Hope, Andrew, Selby, Richard, Mpembele, Fabrice, Mwamba Miaka, Erick, Boelaert, Marleen, Lehane, Mike, Torr, Steve and Stanton, Michelle (2020) 'Impact of tiny targets on Glossina fuscipes quanzensis, the primary vector of human African trypanosomiasis in the Democratic Republic of the Congo'. PLoS Neglected Tropical Diseases, Vol 14, Issue 10, e0008270.
Trypanosoma brucei colonizes the tsetse gut via an immature peritrophic matrix in the proventriculus.
Rose C, Casas-Sánchez A, Dyer NA, Solórzano C, Beckett AJ, Middlehurst B, Marcello M, Haines LR, Lisack J, Engstler M, Lehane MJ, Prior IA, Acosta-Serrano Á. Nat Microbiol. 2020 Jul;5(7):909-916. doi: 10.1038/s41564-020-0707-z. Epub 2020 Apr 20. PMID: 32313202
Tsetse salivary glycoproteins are modified with paucimannosidic N-glycans, are recognised by C-type lectins and bind to trypanosomes.
Kozak RP, Mondragon-Shem K, Williams C, Rose C, Perally S, Caljon G, Van Den Abbeele J, Wongtrakul-Kish K, Gardner RA, Spencer D, Lehane MJ, Acosta-Serrano Á. PLoS Negl Trop Dis. 2021 Feb 2;15(2):e0009071. doi: 10.1371/journal.pntd.0009071. eCollection 2021 Feb.
Scaling up of tsetse control to eliminate Gambian sleeping sickness in northern UgandaHope, Andrew, Mugenyi, Albert, Esterhuizen, Johan, Tirados, Inaki, Cunningham, Lucas, Garrod, Gala, Lehane, Mike, Longbottom, Joshua, Mangwiro, TN Clement, Opiyo, Mercy, Stanton, Michelle, Torr, Steve, Vale, Glyn A., Waiswa, Charles and Selby, Richard (2022) 'Scaling up of tsetse control to eliminate Gambian sleeping sickness in northern Uganda'. PLoS Neglected Tropical Diseases, Vol 16, Issue 6, e0010222.
Estimating the impact of Tiny Targets in reducing the incidence of Gambian sleeping sickness in the North-west Uganda focus Bessell, Paul R., Esterhuizen, Johan, Lehane, Mike, Longbottom, Joshua, Mugenyi, Albert, Selby, Richard, Tirados, Inaki, Torr, Steve, Waiswa, Charles, Wamboga, Charles and Hope, Andrew (2021) 'Estimating the impact of Tiny Targets in reducing the incidence of Gambian sleeping sickness in the North-west Uganda focus'. Parasites & Vectors, Vol 14, Issue 410.