Dr Yang Wu

Senior Research Associate

I graduated from medical university and trained for Msc, Ph.D. in medical research both in China and Western countries. Working experience in medical institutes in China,Canada and UK

Research experience in stress responses and HSPs (1984-1993).  Experience in filarial nematodes (1993-2000) with interests in filarial nematode biology, stage-specific antigen expression, vaccination, and immunology, From 2000 to 2016,  I worked under the supervision of Professor Alister Craig obtained decent knowledge and experience in malarial cytoadherence,  signal transduction and functional proteomics analysis using mass spectrum.   from 2017 to 2019 I have had a chance to work in Francis Crick Institute, London (A fantastic state-of-the-art biomedical and translational research centre) under Malarial Drug Target Discovery Program led by professor Tony Holder, I gained experience of working on drugs, for the discovery and drug target validation.

In  LSTM,  I work in AWOL/Filariasis Lab. under the leadership of Professor Mark Taylor. We are working on the next phase of research of Wolbachia/nematode symbiosis and progress into translational aspects to exploit Wolbachia as a drug target. The project includes drug target identification, mode-of-action of new fast-acting anti-wolbachial drugs and polyomic approaches to further understand the nature of the mutualistic association (genomic/ transcriptomic/ metabolomic and proteomic analysis of key stages of  Brugia Malayi and other filarial nematodes).  

 

 

Research experience in stress responses and HSPs (1984-1993).  Experience in  filarial nematodes (1993-2000) with interests in  filarial nematode biology, stage specific antigen expression, vaccination and immunology, From 2000 to 2016,  I worked under the supervision of professor Alister Craig  obtained decent knowledge and experience in malarial cytoadherence,  signal transduction and functional proteomics analysis  using mass spectrum.   from 2017 to 2019 I have had a chance to work in Francis Crick Institute, London (A fantastic state-of-the-art biomedical and translational research centre) under Malarial Drug Target Discovery Program led by professor Tony Holder, I gained experience of working on drugs, for the discovery and drug target validation.