Dr Michael Abouyannis

Wellcome Academic Clinical Fellow

I am a Wellcome Trust academic clinical fellow currently based at the KEMRI-Wellcome Trust Research Programme in Kilifi, Kenya. My PhD is focussed on improving snakebite clinical trial outcome measures, understanding the burden of snakebite in Kilifi, and assessing the safety and pharmacokinetics of a novel oral therapy.

I studied medicine at the University of Birmingham. My previous clinical experience includes working in emergency medicine and obstetrics in KwaZulu-Natal, and working with Médecins Sans Frontières in a Sudan refugee camp. My past academic experiences include HIV research at the Infectious Diseases Institute in Kampala, and TB and sepsis research in Malawi. I am a Liverpool based specialist registrar in Infectious Diseases, Tropical Diseases and General Medicine.

Research

1) Development of a globally relevant core outcome set for snakebite clinical trials.

2) Description of the burden of snakebite in Kilifi, through household and hospital surveillance.

3) A clinical trial in healthy Kenyan volunteers to understand the safety and pharmacokinetics of a novel oral therapeutic.

Recent publications: 

    Selected publications

    • The 20-minute whole blood clotting test (20WBCT) for snakebite coagulopathy-A systematic review and meta-analysis of diagnostic test accuracy. Lamb T, Abouyannis M, de Oliveira SS, Shenoy K R, Geevar T, Zachariah A, Sharma SK, Bhatt N, Mukaka M, Harriss E, Lalloo DG, Ashley EA, Monteiro WM, Smithuis F, Eddleston M. PLoS Negl Trop Dis. 2021 Aug 10;15(8):e0009657. doi: 10.1371/journal.pntd.0009657. eCollection 2021 Aug. PMID: 34375338 Free PMC article.

      Clinical outcomes and outcome measurement tools reported in randomised controlled trials of treatment for snakebite envenoming: A systematic review. Abouyannis M, Aggarwal D, Lalloo DG, Casewell NR, Hamaluba M, Esmail H. PLoS Negl Trop Dis. 2021 Aug 2;15(8):e0009589. doi: 10.1371/journal.pntd.0009589. eCollection 2021 Aug. PMID: 34339410 Free PMC article.

      Sensitivity of SARS-CoV-2 RNA polymerase chain reaction using a clinical and radiological reference standard. Stockdale AJ, Fyles F, Farrell C, Lewis J, Barr D, Haigh K, Abouyannis M, Hankinson B, Penha D, Fernando R, Wiles R, Sharma S, Santamaria N, Chindambaram V, Probert C, Ahmed MS, Cruise J, Fordham I, Hicks R, Maxwell A, Moody N, Paterson T, Stott K, Wu MS, Beadsworth M, Todd S, Joekes E. J Infect. 2021 Jun;82(6):260-268. doi: 10.1016/j.jinf.2021.04.012. Epub 2021 Apr 20. PMID: 33892014 Free PMC article.

      Is continuous positive airway pressure (CPAP) a new standard of care for type 1 respiratory failure in COVID-19 patients? A retrospective observational study of a dedicated COVID-19 CPAP service. Nightingale R, Nwosu N, Kutubudin F, Fletcher T, Lewis J, Frost F, Haigh K, Robinson R, Kumar A, Jones G, Brown D, Abouyannis M, Beadsworth M, Hampshire P, Aston S, Gautam M, Burhan H. BMJ Open Respir Res. 2020 Jul;7(1):e000639. doi: 10.1136/bmjresp-2020-000639. PMID: 32624495 Free PMC article.

      Population Incidence and Mortality of Sepsis in an Urban African Setting, 2013-2016. Lewis JM, Abouyannis M, Katha G, Nyirenda M, Chatsika G, Feasey NA, Rylance J. Clin Infect Dis. 2020 Dec 17;71(10):2547-2552. doi: 10.1093/cid/ciz1119. PMID: 31725849 Free PMC article.

      Drug resistance of Mycobacterium tuberculosis in Malawi: a cross-sectional survey. Abouyannis M, Dacombe R, Dambe I, Mpunga J, Faragher B, Gausi F, Ndhlovu H, Kachiza C, Suarez P, Mundy C, Banda HT, Nyasulu I, Squire SB. Bull World Health Organ. 2014 Nov 1;92(11):798-806. doi: 10.2471/BLT.13.126532. Epub 2014 Sep 18. PMID: 25378741 Free PMC article.

      Attitudes of serodiscordant couples towards antiretroviral-based HIV prevention strategies in Kenya: a qualitative study. Fowler N, Arkell P, Abouyannis M, James C, Roberts L. AIDS Patient Care STDS. 2015 Jan;29(1):33-42. doi: 10.1089/apc.2014.0210. PMID: 25375792

      Bleeding events and associated factors in a cohort of adult patients taking warfarin in Sarawak, Malaysia. Edwards F, Arkell P, Fong, Roberts LM, Gendy D, Wong CS, Ngu JC, Tiong LL, Bibi FM, Lai LY, Ong TK, Abouyannis M. J Thromb Thrombolysis. 2014;38(2):226-34. doi: 10.1007/s11239-013-1017-6. PMID: 24233388

      Essential therapeutics skills required of junior doctors. Baldwin MJ, Abouyannis M, Butt TF. Perspect Med Educ. 2012 Dec;1(5-6):225-36. doi: 10.1007/s40037-012-0032-1. Epub 2012 Nov 20. PMID: 23240101 Free PMC article.

      Can emergency departments fulfil BASHH recommendations for 24-hour access to HIV postexposure prophylaxis following sexual exposure? Arkell P, Abouyannis M, Manavi K. Int J STD AIDS. 2012 Jan;23(1):75-6. doi: 10.1258/ijsa.2011.011259. PMID: 22362701 No abstract available.

      Development and validation of systems for rational use of viral load testing in adults receiving first-line ART in sub-Saharan Africa. Abouyannis M, Menten J, Kiragga A, Lynen L, Robertson G, Castelnuovo B, Manabe YC, Reynolds SJ, Roberts L. AIDS. 2011 Aug 24;25(13):1627-35. doi: 10.1097/QAD.0b013e328349a414. PMID: 21673555 Free PMC article.