Eva completed her Masters and PhD at the Department of Microbial Ecology, University of Vienna, supervised by Michael Wagner and Matthias Horn, comparing non-pathogenic to pathogenic Chlamydiae. Supported by a Marie-Curie fellowship, Eva moved to the UK to work with Martin Embley at Newcastle University, investigating reductive genome evolution of eukaryotic parasites. Eva then crossed the ocean to Melbourne to work on bacterial cell surfaces in the lab of Trevor Lithgow (Monash University) as a Fellow Laureate Post-Doctoral Research Associate. The offer of a senior staff scientist position at the Wellcome Trust Sanger Institute and her interest in genome evolution brought Eva back to the UK, where she investigated the population dynamics of infectious disease pathogens and how this is impacted by antimicrobial resistance using large-scale genomic datasets, working with the teams of Gordon Dougan and Nicholas R. Thomson.
Eva joined the Vector Biology Department January 2019, to bring together the clinical expertise at LSTM with her expertise in molecular evolution to address the global health threat of spreading antimicrobial resistance, its impact on pathogen populations and the balance between intrinsic and acquired resistance mechanisms.
A main group of projects target the evolution of high-risk lineages in Gram-negative bacterial pathogens, and the impact of antimicrobial resistance on bacterial population dynamics, which will be addressed with comparative genomics, transcriptomics and further large-scale phenotyping.
Projects focusing on mobile elements (phages, plasmids) and their impact on pathogens will be addressed through combining short-read datasets with in-house long-read sequencing (MinION) to resolve structural chromosome rearrangements and plasmid structures.
Research addressing the evolution of bacterial cell surface proteomes for more efficient vaccine design are addressed through large-scale comparative genomics and protein family evolution using hidden markov models (HMM).
Current co-supervision: Gal Horesh, main supervisors Nicholas R. Thomson and Leopold Parts (Wellcome Trust Sanger Institute). Mechanisms of persistence.
25%: Von Vergel Torres, Monash University, main supervisor Prof. Trevor Lithgow. Cellular and molecular imaging of biofilm communities and the effects of antimicrobial peptides. Completed successfully 2018
30%: Pankaj Deo, Monash University, main supervisor Dr. Thomas Naderer. The role of Neisserial "blebs" on host cell biology during infection. Completed successfully 2017
25%: Christopher Stubenrauch, Monash University, main supervisor Prof. Trevor Lithgow. The Translocation and Assembly Module (TAM) participates in the assembly of fimbrial ushers, inverse autotransporters and LptDE. Completed successfully 2016