Mrs Murielle Wondji

Biography

Murielle Wondji, earned a BSc (Hons) in Biomedical Science from Liverpool John Moores University. She then joined the Liverpool School of Tropical Medicine (LSTM) as a Laboratory Technician in the Vector Biology department, Wondji Group, led by Professor Charles Wondji. Currently, as part of the LSTM research unit based at The Centre for Research in Infectious Diseases, Cameroon, she works as the Laboratory Manager, overseeing activities and research projects.

Additionally, Murielle is pursuing a part-time PhD in insecticide resistance, a major challenge in the fight against malaria eradication. Her current research focuses on the mechanisms of mosquitoes, malaria vectors, that allow them to withstand exposure to World Health Organisation-recommended insecticides.

Research interests

As part of her PhD research, Murielle is investigating the role of ATP-Binding Cassette transporters in insecticide resistance in major African malaria vectors. These transporters are phase III metabolism enzymes.

She is interested in assessing their role in insecticide resistance in field populations of anopheles funestus s.s. and anopheles gambiae s.s. analysing their phenotypic response to insecticides, with and without pre-exposure to specific synergists.

Murielle is also conducting transcriptomic profiling analysis to study the expression of ATP-Binding Cassette transporters in A. funestus s.s. and A. gambiae s.s. particularly in populations resistant to pyrethroid insecticides. This is achieved through RNA-Seq data and qRT-PCR for candidate identification.

A phylogenetic analysis of key ATP-Binding Cassette transporters associated with resistance across Africa is performed, and the genetic variants that may drive ATP-Binding Cassette transporter-mediated resistance are explored. The candidate will be functionally validated using in vivo RNA interference (RNAi)and GAL4/UAS transgenesis approaches.

Selected research publications

The E205D mutation in CYP6P3 drives pyrethroid insecticide resistance in the African malaria mosquito vector Anopheles gambiae – Journal: Science Translational Medicine – Published: 4th February 2026

Four-year monitoring of the malaria vector Anopheles funestus in central-west Cameroon reveals an escalation of pyrethroid resistance combined with high malaria transmission – Journal: BMC Infectious Diseases – Published: 28th January 2026

PoolSeq Genome-Wide Association Studies and Microbial Signature Analyses Identify Novel Candidates Associated With Pyrethroid Resistance Evolution in Anopheles funestus in Cameroon – Journal: Molecular Ecology – Published: 5th January 2026

Genomic Drivers of Pyrethroid Resistance Escalation in the Malaria Vector Anopheles funestus Across Africa – Journal: Molecular Biology and Evolution – Published: 24th October 2025

Spatiotemporal changes in prevalence of Sodalis glossinidius, Spiroplasma spp. and trypanosome species in wild Glossina tachinoides from Sora-Mboum animal African trypanosomiasis focus in northern Cameroon – Journal: Insect Science – Published: 1st October 2025

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