Dr Mark Paine

Biography

Dr Paine graduated in Genetics from Wits University, Johannesburg in 1983. In 1990 he obtained his PhD for research on the molecular biology of viper venoms from Liverpool School of Tropical Medicine (LSTM). In 1993 he moved to the University of Dundee Biomedical Research Centre to work on molecular aspects of human drug metabolising enzymes. In 2006 he returned to LSTM to investigate the chemical detoxification mechanisms of insects and identify and characterise the key enzymes associated with insecticide resistance.

Research interests

Dr Paine heads the Enzyme Characterisation Group whose research is primarily aimed at understanding the molecular mechanisms of insecticide resistance and developing tools to accelerate the development of new active ingredients for vector control. This involves the use of a wide range of biochemical, molecular and analytical techniques and collaborations across academia and industry.

Teaching

Dr Paine teaches aspects of vector biology, insecticide resistance and vector control for undergraduate, MSc, Diploma in Tropical Medicine and Hygiene and Diploma in Tropical Nursing modules.

Selected research publications

Multimodal platform for ITN efficacy: Surface chemistry, bioavailability, and mosquito behavior – Journal: Science advances – Published: 8th April 2026

Susceptibility of Anopheles stephensi SDA500 strain to common insecticides and efficacy of glazed tile bioassay for resistance characterization – Journal: Current Research in Parasitology and Vector-Borne Diseases – Published: 5th January 2026

Predictive chemoproteomics and functional validation reveal Coeae6g-mediated insecticide cross-resistance in the malaria vector Anopheles gambiae – Journal: Nature Communications – Published: 28th November 2025

Investigating the potential role of metabolic resistance genes in conferring cross-resistance to pyrethroids and polycyclic aromatic hydrocarbon pollutants in the major malaria vector Anopheles coluzzii – Journal: BMC Genomics – Published: 7th November 2025

The Use of Piper amalago var. amalago as an Eco-Friendly Insecticide Synergist in the Management of Aedes Aegypti – Journal: Journal of Visualized Experiments – Published: 24th October 2025

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