BiVista Study
You are invited to take part in a study to investigate whether a new vaccine that works by stimulating an immune response against Salmonella Typhi and Salmonella Paratyphi A can prevent paratyphoid A fever. In order to test if the vaccine works to protect against paratyphoid A fever, after vaccination with this experimental vaccine or a control vaccine, we will be challenging all participants with the bacteria that could cause paratyphoid fever.
We will also assess the immune response against Salmonella Typhi. The study is being run by the Oxford Vaccine Group, which is part of the University of Oxford, and multiple sites across the UK. The Serum Institute of India are funding the study.
If you are aged 18 to 55 years old, and in good health, then you may be eligible to take part in the study. We will provide reimbursement for your time, inconvenience, and travel. Participants will receive up to £4500 if they remain in the study for the entire period and attend all the scheduled visits required for them. The total study participation time is 7 months, during this time you will be required to attend the Liverpool School of Tropical Medicine for all study visits and the Liverpool School of Tropical Medicine on challenge day.
If you would like to find out more, please read the Participant Information Sheet:
If you are interested in joining the study, please access the screening questions and register your interest: