Mr Dylan Postmus
- Research Associate, Tropical Disease Biology
Biography
Dylan Postmus is a Research Assistant and Biomedical Sciences PhD candidate (at Free University, Berlin), currently working under the supervision of Professor Christine Goffinet, in the Tropical Disease Biology department at Liverpool School of Tropical Medicine. His research mainly involves studying HIV-1 latency, virus-host interaction and experimental HIV cure strategies using ‘wet lab’ molecular biology techniques and bioinformatic approaches.
Research interests
Dylan’s main research interests include understanding how HIV-1 establishes and maintains latent infection, and how biological insights into this could be leveraged to reverse latent infection in the interest of allowing host immune mechanisms to clear infected cells – a strategy commonly referred to as the ‘Shock and Kill’ HIV cure strategy. To study this, he employs a mixture of standard molecular biology techniques, flow cytometry, genomics, transcriptomics and, most recently, epigenomics.
Selected research publications
Neural network-assisted humanisation of COVID-19 hamster transcriptomic data reveals matching severity states in human disease – Journal: eBioMedicine – Published: 23rd September 2024
Single-cell-resolved interspecies comparison shows a shared inflammatory axis and a dominant neutrophil-endothelial program in severe COVID-19 – Journal: Cell Reports – Published: 10th June 2024
TMPRSS2-mediated SARS-CoV-2 uptake boosts innate immune activation, enhances cytopathology, and drives convergent virus evolution. – Journal: Proceedings of the National Academy of Sciences of the United States of America – Published: 4th June 2024
90K/LGALS3BP expression is upregulated in COVID-19 but may not restrict SARS-CoV-2 infection – Journal: Clinical and Experimental Medicine – Published: 1st November 2023
Pharmacological inhibition of bromodomain and extra-terminal proteins induces an NRF-2-mediated antiviral state that is subverted by SARS-CoV-2 infection – Journal: PLoS Pathogens – Published: 25th September 2023
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