Pharmacodynamics of Intracellular Pathogens for the optimization and/or development of new treatments

This is an exciting opportunity to work with one or more intracellular pathogens including Plasmodium, Mycobacterium tuberculosis, Salmonella, N. gonorrhoeae and Chlamydia trachomatis. Projects typically involve Industry and overseas training placements. Host-pathogen interactions will be studied using live Imaging- based platforms as well as general techniques in molecular biology, analytical/metabolomics/proteomics and potentially microfluidics. Quantitative skills training will include basic or advanced pharmacodynamic- pharmacokinetic (PK-PD) modelling approaches.  The projects will be tailor-made to involve clinical/field components.

Where does the project lie on the Translational Pathway?

T1 Basic Research + T2 Human/Clinical Research

Expected Outputs

Publications and proof-of-concept data for grant funding and on-ward clinical research towards changing practice

Training Opportunities

Industry placements specific pharmacodynamics training, Hospital placements for exposure of clinical context of disease (e.g. Malawi or Vietnam) and/or training in clinical microbiology skills (e.g. break points etc). External scientific laboratories for specialised platform training e.g. Imaging, microfluidics and PK-PD training.  MRes placements may also involve qualitative research.

Skills Required

Solid Biology/Pharmacology/Pharmacy/Medical background or alternatively a maths-orientated background but from someone with interest in tackling real-life clinical knowledge-gaps/health issues.

Key Publications associated with this project

Ghaith Aljayyoussi G,  Jenkins VA, Sharma R, Ardrey A, Donnellan S, Ward SA, Biagini GA. Pharmacokinetic-Pharmacodynamic modelling of intracellular Mycobacterium tuberculosis growth and kill rates is predictive of clinical treatment duration.  Scientific Reports.  In press


O'Neill, P et al., A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance"Nature commIn press


Ismail HM, Barton V, Phanchana M, Charoensutthivarakul S, Wong MH, Hemingway J, Biagini GA, O'Neill PM, Ward SA. Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasites Plasmodium falciparum 3D7. Proc Natl Acad Sci U S A. (2016) 113(8):2080-5.



LSTM Themes and Topics – Key Words

Malaria, Lung health and TB, Resistance Research and Management

Deadline: Thursday 11th February 2021; 12:00 noon GMT

Further details on the MRC/DTP and CASE programmes and application guidance and process can be found here